Here is mine.

It's whacky but ... some sense in it ?? - extravert people respond differently from introvert people ....as a person, concerned more with prompt reaction to the external practical realities than with inner thoughts and feelings, drawn to novelty and people; lost when isolated and with nothing to - when they are likely to fond something to do raher than read.

The two personalities are constant in their basic behaviours, throughout their lives, to the extent that it can be presumed for hypthesis that their brains are hard-wired differently. The direction in the ways they appreciate and respond to the world coming from from their genes to the end-point pf brain development will be different

What happens when one parent is E and the other spouse O. Extroverts cannot be introverts - cannot change ' their spots '. ... ... how do their genes compromise in brain connection building after any conception between them ???

Any Ideas ???

E-mail reaction is very welcome ,,, click on mica@jidgey.e7even.com

The embryo develops after the zygote is formed from the fusion of the sperm nucleus with that of the receiving egg.

Initial genetic fusion, and therefore early future development can be experimentally confined either to two male nuclei or to two female nuclei in the zygote

...[ in animal zygote studies where the male contribution to fertilisation has entered but not joined in, its nucleic bit can be sucked out and replaced by a second half of the female nucleic contribution, leading to a zygote whose whole genetic instruction is female derived....result ... embryonic development is restricted to the upper brain, the cerebral cortex.

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When the complimentary study is made - the male nucleic contribution is left , the female resident nucleic component removed and replaced by another male half ... result ... the embryonic development proceeds to placental attachment and the lower brain only....

The boundary is ill-defined because development progress is halted.

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The male contribution is responsible for that 'below' brain up [ active skills ] to where the upper mid-brain meets with the upper cortex ; the female derived contribution looks after the cortical half above -storing skills that fit people into the world - and with other people.

The genetic instruction for the brain seems to divide into a male and a female contribution.

So: the cerebellum to the thalamus is maybe male code driven; the thalamus upward female code driven.

The thalamus may may be a 'battle ground'.

The cerebellar - thalamic - cortical connection is believed to be concerned with storing habitual stances there to be called upon in the future., and maybe stored experience as a whole, updated through the temporal lobes and the hippocmpus.
The bicycle may be different - the car may be different - but the stored grouping of the basic necessary 'meta 'skills remain available to meet the potential changes that memory says may come with a slightly different actuality; the basic skill already there can be dusted up to be on hand.

It seems likely that this is not just - I am going to get on my bike now - assemble all the skill bits required for me get through the bike to the supermarket - but likely the more complicated external expectations in basic sequential decisions such as - this is my days programme - I will be seeing so-and -so ... dealing with that person reporting to this other one ... - what social skills will I be able to come up with, to be ready to associate within the context of this day - how am I going to handle XYZ - find yesterday's left-overs - remember to get that for the garden - to get that posted... etc... , and fit all into tomorrow's - next week's programme.

Suppose we agree, extravert people are genetically different in brain wiring from introvert people The one cannot be the other [ or midline ].

From this how can it be that some disconnection comes about in the brain development in those who develop schizophrenia?
So that the proper associations - the prepared habits - do not come up, or appear in-approriately?

That is the question?

PET brain scans reveal that introverts have more activity in the frontal lobes of the brain and anterior, or front, thalamus.
These areas are activated when a person's brain takes on internal processing such as remembering, problem solving and planning.Faced with a problem, introverts go to the past

Extroverts exhibit more activity in the anterior cingulate gyrus, temporal lobes and posterior thalamus.
These areas are typically thought to be more involved in sensory processing such as listening, watching or driving.

Extroverts get closer to acting, more touchy in both senses [ 'what they think they have already said' - as someone once said about an extrovert - which typically the extrovert resented at once ] The differences in cognitive style and sensory-processing relate to the qualities associated with introversion and extroversion. True introverts are quiet, inwardly focused, wary, hidden, cautious and reclusive if challenged. Extroverts are gregarious, socially active, immediatedly outward, attention and sensation seeking, reacting immediately to criticism. 'what they think they have already said'

Introverts get more of their stimulation internally, whereas extroverts seek outside sources.

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What will happen if a male genetically programmed lower brain end is programmed to an introvert pattern of connecting from the contribution of an introverted sperm, and the upper brain half ( the female genetic instruction ) is programmed through the ovum nucleus to exert an extrovert pattern of realisation of the interplay with the world: or, vice versa ?

Assume again that a lot of pruning and re-wiring goes on in adolescence the sexual releaser divide, - the age between sixteen and twenty four - to borrow the definition of Shakespeare . And this is the age when schizophrenia shows its first overt signs.

What happens during this time of extended puberty and adolescence is the efflorescence and exhibition of male and female hormones with a good deal of hormone receptor addition or awakening in the brain? [ may it be that some taming of the aggression that comes alongside with androgens is required, so pruning dampens the aggressive reaction ? ]

It is also the time when childhood habits towards parenting of conformity of behaviour and attitudes, are discarded in favour of picking up or confirming as fresh, the signposts and standards for the 'new' emancipation from parenting towards the emerging adult individual.

The adolescent anxieties

Will there not be a collision and an aggravation in the connection business, if there has been an already uneven balance between introvert and extrovert in earlier brain development and connection?
Especially where the adolescent hormonal under-pinning supports either of the one-sided personalities.

In this UK culture here are more introverts in males [ but n.ireland v eire ] ; there are more extroverts in females. ?

Introversion goes with strong habits; extroversion with an eye to novelty.
This is not a match.

Could it be that balanced rewiring is set aside by an excess on one side or the other?

With a flight of imagination - and what are hypotheses but that in the beginning - maybe -

male ( Introvert sperm )++male adolescence/female( extrovert egg )= schizophrenia. or vice versa - male extrovert sperm plus introvert ovum = leads to bipolar ?

introvert male and female - obssessional endpoint: extrovert plus extrovert - Attention Deficit Hyperactivity Syndrome[ ADHS ] trouble ?

The cerebellar - thalamic - cortical connection is believed to be concerned with the realigning and collecting together of habitual accumulations - to bring about the overall present mental intention - cycling as a habit. These areas are activated when a person's brain takes on internal processing such as remembering, problem solving and planning.

Brain imaging shows also that , where in some people who develop schizophrenia there is enlargement of the ventricles - brain change - it is a once only thing - especially around adolescence and then stays without progression, - as neuro-cognitive studies also seem to show it.

Another imaging study on developing childhood schizophrenia shows a dramatic change in the parietal lobe two years before the arrival of the 'structural changes in brain - found in the adult schizophrenia arriving at that later time . .

The parietal lobe processes enviromental sensation, so that it acquires meaning and relevant significance.
People with longstanding schizophrenia in mental hospital, didn't seem to register chronic pain at all. One way of diagnosing schizophrenia used to be by examining the teeth. They were generally bad to an extent which would be expected to give pain in ordinary people. But the experience of chronic pain can be lost or set aside in schizophrenia - shunted into a different reception category. Patients could be seen in hospital with swollen teeth abscesses which they seemed to disregard. Lancinating pain from the lung lining was attributed to 'birds pecking' and the irregularity of heart beats down to birds wings flapping.
The sensations had gone into a different interpretive direction. The connections are different.

Extrovert people go towards novelty and engage people; introvert people are careful and wary of the new - stick to old habits. The differences may come from the frontal lobe government of what the parietal lobe sends up. The frontal lobe may have to favour or suppress particular parietal receipts - in keeping with the general attitude of the personality.

The parietal lobe changes seen early in childhood schizophrenia may disturb the way in which the frontal lobe draw things together: gate-keeping may go awry ??

Clinical studies conclude that the illness effects settle to a compromise after about fifteen years, so that a patient can live with the illness continuing but not dominating and still allow the individual to connect sufficiently for a social life.

The ability to form networks of connections presumably endures, or can be rebuilt and remain available to establish themselves, if outside engagment in activities can be set up, can be made possible and can be sustained by continuing support over time. That will require sheltered opportunities for the taking part.

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