So, hippocampus early development is an important start to think how and why things have gone wrong.
perinatal asphyxia and hippocampus damage
Perinatal hippocampus damage
explained in The scientist Journal
pruning: does immunity play a part
Hippocampus:- anatomy and function
Sekar et al :- Abtract
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C4A. Human C4 protein localized to neuronal synapses, dendrites, axons, and cell bodies. In mice, C4 mediated synapse elimination during postnatal development. These results implicate excessive complement activity in the development of schizophrenia and may help explain the reduced numbers of synapses in the brains of individuals with schizophrenia.
attention fixes hippocampus
two memories co-operates
stress shifts the memory stream
thalamic spindling: background
a Hub like this
adolescence is a time of brain 'pruning'.
New August 2017 :-
Human Brains need the structure of a a Story
Gazzinga, studying 'splitbrain' patients done for epilepsy suppresion concluded that the left brain does the cognitive and analytic work: the right brain organising the sensory/motor networks. He tries out Mood influence.
The effect of reacting to a fear producing movie
Using a very elaborate optical computer system that detects the slightest movement of the eyes, we were able to project a movie exclusively to the left visual field. If the patient tried to cheat and move her eyes toward the movie image, the projector would automatically shut off. The movie her right hemisphere saw was about a vicious man pushing another man off a balcony and then throwing a bomb on top of him. It then showed other men trying to put out the fire. When VP was ? re- tested on this problem, she could not access speech from her right hemisphere. When asked about what she had seen, she said, "I don't really know what I saw. I think just a white ash." I asked, "Were there people in it?" VP replied, "I don't think so. Maybe just some trees, red trees like in the fall." I asked, "Did it make you feel any emotion?" VP said, "Maybe I don't like this room, or maybe it's you, you're getting me nervous." Then VP turned to one of the research assistants and said, "I know I like Dr. Gazzaniga, but right now I'm scared of him for some reason."
This experimental evidence merely illustrates a rather extreme case of a phenomenon that commonly occurs to all of us. Our mental systems set up a mood that alters the general physiology of the brain. In response, the verbal system notes the mood and attributes a cause to the feeling based on available evidence. ? the delusion develops.