Sekar et al :- Abtract
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C4A. Human C4 protein localized to neuronal synapses, dendrites, axons, and cell bodies. In mice, C4 mediated synapse elimination during postnatal development. These results implicate excessive complement activity in the development of schizophrenia and may help explain the reduced numbers of synapses in the brains of individuals with schizophrenia.
the connection of immunity response to a cause of pruning,leading to schizophrenia
If immunity plays a part, might it lead to new treatment ;- go to So, why not have a go.
might it raise questions about capacity to fully understand, to give informed consent.
Side effects of monoclonal anti bodies: Natalizumab
perinatal asphyxia and hippocampus damage
Perinatal hippocampus damage
attention fixes hippocampus
two memories co-operates
stress shifts the memory stream
thalamic spindling: background
go to Striatum Studies
a Hub like this
adolescence is a time of brain 'pruning'.
New August 2017 :-
Human Brains need the structure of a a Story
Gazzinga. studying 'splitbrain' patients done for epilepsy suppresion concluded that the left brain does the cognitive and analytic work: the right brain organising the sensory/motor networks.
New hippocampus academic research
Important - current academic references
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