References : -

1.
Measuring memory impairment in community-based patients with schizophrenia
J. Bruce, MBChB, MRCPsych, S. Frost, MBBS, MRCPsych and D. Mackintosh, MBChB, MRCPsych
B J PSYCHIATRY 2006 189 132-13

1(a)Cognitive function in a catchment - area - based population of patients with schizophrenia
CIARA KELLY, VAL SHARKEY, GARY MORRISON, JUDITH ALLARDYCE, and ROBIN G. McCREADIE The British Journal of Psychiatry 2000 v. 177, p. 348-353.
Nithsdale Schizophrenia Surveys 20

2.
stem cell proliferation is decreased in schizophrenia, but not in depression
A Reif,, S Fritzen,, M Finger, A Strobel, M Lauer, A SchmittK-P Lesch Molecular Psychiatry (2006) 11, 514-522
Reif et al 2006


2(b)Allen et al

the most important finding - never reproduced directly but subsequent studies [ see below ] give confirmation - as does the inability of continuing sufferers to accumulate maturing experience after the age at which the illness - they stick in the area of interest and at the level of personal domestic and social competence they had before the illness - their friends and family move ahead and away, they are left behind.: they lose natural support and mentoring

2(c)

Coras et al studied how stem cells in a memory-related region of the brain, called the hippocampus, proliferate and change into different types of nerve cells.
Over the past two decades, several studies have shown that new nerve cells are generated in the hippocampus.
In animal studies, disrupting nerve cell generation resulted in the loss of memory function, whilst increasing the production of new nerve cells led to improved memory.

To investigate whether the same is true in humans, the UF researchers, in collaboration with colleagues in Germany, studied 23 patients who had epilepsy and varying degrees of associated memory loss.
They analyzed stem cells from brain tissue removed during epilepsy surgery, and evaluated the patients' pre-surgery memory function.
In patients with low memory test scores, stem cells could not generate new nerve cells in laboratory cultures, but in patients with normal memory scores, stem cells were able to proliferate.

That showed, for the first time in HUMAN TISSUE a clear correlation between patient's memory and the ability of their stem cells to generate new nerve cells.

2017

Changes preceding schizophrenia

Psychiatric Times link: Seidman et al. working memory failure is early warning
seidman plus reference link

schizophrenia:reduced left hippocampus


idiosyncratic speech precedes schizophrenia

3.
Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia
JM Gold, Ph.D., Hahn, Ph.D., Zhang, Ph.D. Robinson, , Kappenman, , Beck, , and Luck, Ph.D. Arch Gen Psychiatry. 2010 June ; 67(6): 570-577.
link to the Gold et al paper

3.
Automatization and working memory capacity in schizophrenia
Tamar R. van Raalten , Nick F. Ramsey , J. Martijn Jansma , Gerry Jager a, René S. Kahn / Schizophrenia Research 100 (2008) 161-171
Raalten

This study now confirmed :-

Koch et al Koch et al
"... First evidence from studies with schizophrenia patients indicates that the potential to profit from short-term practice under stable learning conditions
(ie, when the same stimulus material is repeatedly being processed)s

Das et al dental gyrus
This data suggest that the dentate gyrus is dysfunctional in schizophrenia, a feature that could contribute to declarative memory impairment in the disorder and possibly to psychosis, a conclusion consistent with the considerable molecular pathology in the dentate gyrus in schizophrenia

b.Stan et al
glutamate dental gyrus

Fuerte et al 2006 ] with poor background contextFuerte et al 2006 ] with poor background context

4.

Teng KY et al early lesion: late effect Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA.

Animals with a neonatal ventral hippocampal lesion (NVHL) develop abnormal behaviors during or after adolescence,
suggesting that early insults can have delayed consequences.
4a.
Lecourtier
Intact neurobehavioral development but dramatic impairments of procedural-like memory following Neonatal Ventral Hippocampal Lesion [ NVHL ] in rats.
early hippo rat lesion gives late adolescent memory problem

5.
Measuring memory impairment in community-based patients with schizophrenia
J. Bruce, MBChB, MRCPsych, S. Frost, MBBS, MRCPsych and D. Mackintosh, MBChB, MRCPsych
B J PSYCHIATRY 2006 189 132-13

6.
Cognitive function in a catchment - area - based population of patients with schizophrenia
CIARA KELLY, VAL SHARKEY, GARY MORRISON, JUDITH ALLARDYCE, and ROBIN G. McCREADIE The British Journal of Psychiatry 2000 v. 177, p. 348-353.
Nithsdale Schizophrenia Surveys 20

7.
targeting of the CA1 sub- field of the hippocampus by schizophrenia and related psychotic disorders.
Scott A. Schobel; Nicole M. Lewandowski; Cheryl M. Corcoran; Holly Moore;
September Archives of General Psychiatry, 2009
hippocampal change preceding and bringing on schizophrenia

some confirmation

Mecheli et al
Archives General Psychiatry 2011 May;68(5):489-95.
Neuroanatomical abnormalities that predate the onset of psychosis: a multicenter study.

8.
Brita Elvevaag, Elizabeth A Maylor, Abigail L Gilbert
[ BMC Psychiatry 2003.3.0 research article open access ]
Rehearsing a game chase test sufferers do as well as controls - but when given a concurrent task, they fail on it, some even then declaring it was done.

9.
Coras et al:- Brain 2010: 133; 3359 .... As in rodent studies , in humans also, there is a correspondence is found between the level of human hippocampal neurogenesis cells and the level of effective working memory.

10.
tamminga
a hippocampal hypothesis: pattern separation failure .... but how does that produce a coherent delusion system ?

11.
Abstract

Lodge

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