NEW :- add on monthly items
The speech features that predicted psychosis onset included breaks in the flow of meaning from one sentence to the next, and speech that was characterized by shorter phrases with less elaboration.
The speech classifier tool developed in this study to mechanically sort these specific, symptom-related features is striking for achieving 100% accuracy.
The computer analysis correctly differentiated between the five individuals who later experienced a psychotic episode and the 29 who did not.
These results suggest that this method may be able to identify thought disorder in its earliest, most subtle form, years before the onset of psychosis.
Thought disorder is a key component of schizophrenia, but quantifying it has proved difficult.
Here are the changes in the brain that lead into schizophrenia
Confirmed !!! Allen et al
This is the original finding - ignored !! Reif et al 2006 - Reif et al 2006
the most important finding Reif et al 2006 now replicated and confirmed.
NINE YEARS LATE
... Allen et al l a Quote- if linking is difficult ( We find a decrease in cell proliferation in the anterior hippocampus of people with schizophrenia, confirming the results of previous studies that have suggested a deficit in hippocampal cell proliferation and of neurogenesis in schizophrenia [ Reif et al ] in an independent cohort. Our results are consistent with those of Reif; however, we found a slightly larger decrease in Ki67 expression (60% in the current study vs 50% in [Reif et al ] ) Allen et al 2015
Those who go on to continuing schizophrenia do so because the hippocampus region in their brain - the gate-keeper between the inside and the outside world - has to manage this with only half the new cell provision to the hippocampal functioning that heathy people require to be available to be able to cope with all the changes in day to day living - sorting out the wheat - necessary - from the chaff - ignore
People with continuing schizophrenia suffer from information overload.
The hippocampal gate-keeping function - keeping out irrelevant information whilst allowing in useful experience - can't cope with only half the usualhippocampal new cell provision- unsettling - letting some incomig stimuli to go directly, 'uncensored ' ,
to the striatal memory net work - normally used for procedural learning - habits - grammar bicycle riding: relative to the hippocampal stream where stored material can be consciouly sought, the striatal route is less flexible, less conscious, less accessible, uses a different net work to consolidate what it has taken in, and where dopamine imprints value on what is passing through.
Stand out material that gets into storage this way is abnormal, carries anxiety with it, yet has to be dealt with,- given an account - so becomes consolidated as an explnatory delusional system, normally segregated ,but gone too when newhigh anxiety further reduces hippocampal new cell formation,
Updated news February ... an ill journey
Carers Corner Cornwall Mental Health Trust lets carers see online what affects them.
The Teams today ....
Their most important duty The system in place that ensures any matters of uncertanty that touch carers' caring in a local Trust Mental health Community catchment area service are discussed at the local Community Mental Health team weekly meeting where the members present are listeded, and the outcome is on Record
SchizophreniaWatch :- February 2015:
A UK website, principally for carers about and carers for schizophrenia; family, community, and professional service caring, who should - must ! - give voice for the best interests of those cared for they can't, won't, theydon't, voice for themselves.
The site is edited by a retired psychiatrist who has looked after someone with the schizophrenia condition, at home, affected by the negative form of schizophrenia, for the last twenty years. [The blue highlit links take you to another page.. ] You return via the back arrow at the top of your screen or from a link at the bottom of a page
I hope this will leave me space better to explain where the caring burden can be relieved of some of the anxieties . Time will tell. Or you can tell me ! ]
Carers and those who live day to day with the illness have no doubts that it is an illness.
There is a break change in observed behaviour from before, sometime placing the person in alien behaviour, to their disadvantage, which they are unable to reverse themselves to regain the previous state.
The illness continues on it's 'course' with the same pattern of behaviour and misbelief, as an autonomous system, isolating the person from others, who cannot identify with the changed behaviour by using their own experience to understand it. What has happened.?
The disabling change is a failure to sustain new cell formation [ neurogenesis ] in the hippocampus area of the brain.
[ In 2006 a study, found in continuing schizophrenia reduced new cell activity in the hippocampus
Reif et al ..see At the age this happens schizophrenia follows. ]
The hippocampus connects any information in the brain to anywhere else in the brain. Especially new information that requires a response.
To do this the hippocampus area has a continual production line of new cells from a stem cell line in the hippocampal dental gyrus . The new cells function as a transient holding area in the brain until whether or not the new information is 'seen' as useful and goes elsewhere. The new cells then disappear making way for a fresh replacement line.
Continuing hippocampal new cell formation is necessary for fitting new useful happenings into an accessable stored away experience.
BLOCKQUOTE> After schizophrenia the hippocampus area of the brain either is not carrying enough stem cells; or, it is not turning stem cells into enough neurons.
Without enough new cells [neurogenesis] in the hippocampus, what is going on outside is not always fully attended to. Nor is irrelevant material kept out. Rather it is taken in as information that has a personal significance, to be explained in some way by a re-arrangement of belief - a delusional system held separately in a brain network, that cannot be challenged.
Schizophrenia is caused by working memory failure. It comes from a failure in hippocampal new cell production. That leads to less 'working memory' .
That is how it is that at the age the illness arrives they do not move on in their lives. The earlier the illness arrives the less accumulated living experience they have to draw upon.
Working memory is what keeps the ability to draw from accumulated experience the particular bits of information required to cope with what crops up during the day . An active working memory is what keeps you up to date: keeps you going.
Team behaviour - it may not be what you assume it is - ! Two cautionary case (1) studies ( 1) ( 2 ) 340 more
Unlike other medical illnesses the brain is removed from immediate access without the risk of damage. There can be no biopsy , no test for the change at the time of the onset of the illness. This has been the biggest challenge to accepting schizophrenia as an illness.
Families are put off by a lack of instruction about the the procedures involved, by the effect it might have upon funeral arrangements, practical and emotional within the family obligations.
The absence of Brain tissue to study is hampering research that would better explain the illness, would make it better understood, would lessen the stigma that comes with a fear from ignorance about what to do.
A Local Authority comments on the Care Act..... the new duties towards carers e.g....clause10,20;42-47 duty of safe guarding , 67-68 advocacy,